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AZD-7648
CAS No. : 2230820-11-6
MCE 国际站：AZD-7648
产品活性：AZD-7648 是一种具有选择性的口服有效 DNA-PK 抑制剂，IC50 值为 0.6 nM, AZD-7648 诱导细胞凋亡 (apoptosis)，具有抗肿瘤活性。
研究领域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR | Apoptosis
作用靶点：DNA-PK | ATM/ATR | PI3K | Apoptosis
In Vitro: AZD7648 (0-30 μM) is a potent radiosensitizer.
AZD7648 (3 μM) increases sensitivity to doxorubicin.
AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib.
In Vivo: AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression.
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