FITC标记的MKLN1抗体
产品名称： FITC标记的MKLN1抗体
英文名称： Anti-MKLN1/FITC
产品编号： HZ-13655R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MKLN1/FITC Conjugated antibody
FITC标记的MKLN1抗体
| 英文名称 | Anti-MKLN1/FITC |
| 中文名称 | FITC标记的MKLN1抗体 |
| 别 名 | MKLN 1; Mkln1; MKLN1_HUMAN; muskelin 1, intracellular mediator containing kelch motifs; Muskelin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 85kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MKLN1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Muskelin is a 735 amino acid nuclear and cytoplasmic protein that mediates cytoskeletal responses and cell spreading to Thrombospondin 1, an extracellular matrix glycoprotein. Forming a CTLH complex with RMND5A, Ran BP-M and TWA1, Muskelin exists as two alternatively spliced isoforms. Muskelin is implicated as an isoform-specific anchoring protein for the prostaglandin EP3 receptor, and contains one LisH domain, a CTLH domain, six Kelch repeats and an N-terminal discoidin-like domain through which it self-associates via a head-to-tail mechanism. Human and mouse Muskelin share 98% amino acid seqeuence homology and are encoded by genes located on chromosomes 7q32.3 and 6 A3.3, respectively. Function: Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin 1. Subcellular Location: Cytoplasm. Similarity: Contains 1 CTLH domain. Contains 6 Kelch repeats. Contains 1 LisH domain. Database links: Entrez Gene: 4289 Human Omim: 605623 Human SwissProt: Q9UL63 Human Unigene: 44693 Human Unigene: 696143 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
麝香素是一种735个氨基酸的核蛋白和细胞质蛋白，介导细胞骨架反应和细胞向凝血酶原1（一种细胞外基质糖蛋白）扩散。用RMND5A、RAN BP- M和TWA1形成CTLH复合物，Muskelin作为两个交替剪接的异构体存在。麝香素是前列腺素EP3受体的同型特异性锚定蛋白，包含一个LisH结构域、一个CTLH结构域、六个Kelch重复序列和一个N端盘状结构域，通过该结构域，麝香素通过头尾机制自我结合。人和小鼠麝香的氨基酸序列同源性为98%，分别由7q32.3和6A3.3染色体上的基因编码。