SERPINB11,丝氨酸蛋白酶抑制剂B11抗体

产品编号HZ-9212R
英文名称SERPINB11
中文名称丝氨酸蛋白酶抑制剂B11抗体
别 名EPIPIN; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 11 antibody Serpin B11 antibody Serpin peptidase inhibitor clade B (ovalbumin) member 11 antibody SERPINB11d antibody SERPINB11e antibody SERPINB11f; SPB11_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
SERPINB11,丝氨酸蛋白酶抑制剂B11抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SERPINB11
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SERPINB11,丝氨酸蛋白酶抑制剂B11抗体PubMedPubMed
产品介绍background:
The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. SerpinB11 (serpin peptidase inhibitor, clade B (ovalbumin), member 11), also known as EPIPIN or SERPIN11, is a 392 amino acid cytoplasmic protein that belongs to the Ov-serpin subfamily and serpin family. Like other members of the serpin family, SerpinB11 has been identified as a noninhibitory intracellular protein. The gene encoding SerpinB11 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.

Function:
Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.

SERPINB11,丝氨酸蛋白酶抑制剂B11抗体Similarity:
Belongs to the serpin family. Ov-serpin subfamily.

Gene ID:
89778

Database links:
Entrez Gene: 89778 Human
SwissProt: Q96P15 Human
Unigene: 350958 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.