FITC标记的神经细胞粘附分子2抗体
产品名称： FITC标记的神经细胞粘附分子2抗体
英文名称： Anti-NCAM2/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NCAM2/FITC Conjugated antibody
FITC标记的神经细胞粘附分子2抗体
| 产品编号 | bs-11094R-FITC |
| 英文名称 | Anti-NCAM2/FITC |
| 中文名称 | FITC标记的神经细胞粘附分子2抗体 |
| 别 名 | N CAM 2; N CAM 21; N CAM2; N CAM21; N-CAM-2; NCAM 2; NCAM 21; NCAM-2; Ncam2; NCAM2_HUMAN; NCAM21; Neural cell adhesion molecule 2; OCAM GPI; R4B12; RB 8 neural cell adhesion molecule; RB8 neural cell adhesion molecule; RNCAM. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞粘附分子 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 91kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NCAM2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NCAM2 is an 837 amino acid protein encoded by the human gene NCAM2. NCAM2 contains five immunoglobulin-like domains, two Fibronectin type III domains, a transmembrane domain and a cytoplasmic domain. The gene is expressed most strongly in human adult and fetal brain. NCAM2 is a member of the neural cell adhesion molecule (NCAM) family. NCAMs are closely related cell surface glycoproteins involved in cell to cell interactions during growth and are thought to play an important role in embryogenesis and development. NCAM2 is a considered a good candidate for involvement in certain Down syndrome phenotypes because a slight overexpression of NCAMs increases many-fold the homotypic adhesion properties of cells. Stat5 regulates NCAM2 in vivo by binding to the NCAM2 intron in the NKL natural killer cell line; this binding is induced by cytokines that activate Stat5. Neither Stat1 nor Stat3 bind to this region, despite sharing a consensus binding sequence with Stat5. Function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons. Subunit: Contains 2 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Subcellular Location: Cell membrane. Tissue Specificity: Expressed most strongly in adult and fetal brain. Similarity: Contains 2 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 4685 Human Entrez Gene: 17968 Mouse Entrez Gene: 288280 Rat Omim: 602040 Human SwissProt: O15394 Human SwissProt: O35136 Mouse Unigene: 473450 Human Unigene: 433941 Mouse Unigene: 138756 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NCAM2是由人类基因NCAM2编码的837氨基酸蛋白。NCAM2包含五个免疫球蛋白样结构域，两个纤连蛋白Ⅲ型结构域，跨膜结构域和胞质结构域。该基因在和胎儿脑中表达最强。NCAM2是神经细胞黏附分子（NCAM）家族的成员。NCAM是细胞生长过程中与细胞间相互作用密切相关的细胞表面糖蛋白，在胚胎发生和发育过程中起着重要的作用。NCAM2被认为是参与某些唐氏综合征表型的一个很好的候选，因为NCAM的轻微过表达增加了细胞的同型粘附特性的许多倍。STAT5通过结合NKL天然杀伤细胞系中的NCAM2内含子调节NCaM2在体内；这种结合是由激活STAT5的细胞因子诱导的。STAT1和STAT3都不与该区域结合，尽管与STAT5共享一个一致的结合序列。