FITC标记的胱抑素8/半胱氨酸蛋白酶抑制剂8抗体
产品名称： FITC标记的胱抑素8/半胱氨酸蛋白酶抑制剂8抗体
英文名称： Anti-CST8/FITC
产品编号： HZ-9216R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CST8/FITC Conjugated antibody
FITC标记的胱抑素8/半胱氨酸蛋白酶抑制剂8抗体
| 产品编号 | bs-9216R-FITC |
| 英文名称 | Anti-CST8/FITC |
| 中文名称 | FITC标记的胱抑素8/半胱氨酸蛋白酶抑制剂8抗体 |
| 别 名 | CRES; CST 8; Cst8; CST8_HUMAN; cystatin 8 (cystatin related epididymal specific); Cystatin 8; Cystatin related epididymal specific; Cystatin related epididymal specific protein; Cystatin related epididymal spermatogenic protein; Cystatin related protein epididymis specific; Cystatin-8; Cystatin-related epididymal spermatogenic protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CST8/Cystatin 8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The cystatin superfamily is a well-established family of cysteine protease inhibitors. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, while some also inhibit legumain family enzymes. The CRES (cystatin-related epididymal spermatogenic) protein defines a new subgroup in the family 2 cystatins of the cystatin superfamily. CRES proteins lack two of the three consensus sites necessary for the cystatin inhibition of C1 cysteine proteases. They are also preferentially expressed in postmeiotic germ cells, the proximal caput epididymidis, and anterior pituitary gonadotrophs. Therefore, CRES proteins may perform unique and tissue-specific functions in the reproductive and neuroendocrine systems. As a member of the CRES subfamily, Cystatin 8 is a 142 amino acid protein that is expressed in the proximal caput region of the epididymis, where it performs a specialized role during sperm development and maturation. Function: Performs a specialized role during sperm development and maturation. Subcellular Location: Secreted. Tissue Specificity: Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium. Similarity: Belongs to the cystatin family. Database links: Entrez Gene: 10047 Human Entrez Gene: 13012 Mouse Entrez Gene: 29679 Rat Omim: 608683 Human SwissProt: O60676 Human SwissProt: P32766 Mouse SwissProt: O88969 Rat Unigene: 121602 Human Unigene: 20435 Mouse Unigene: 18514 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
半胱氨酸蛋白酶抑制剂超家族是一个成熟的半胱氨酸蛋白酶抑制剂家族。所有真正的半胱氨酸蛋白酶抑制剂抑制木瓜蛋白酶家族的半胱氨酸肽酶，如组织蛋白酶，而一些也抑制LeGuMe家族酶。Cys（胱抑素相关附睾生精）蛋白在胱蛋白酶抑制剂超家族的2个半胱氨酸蛋白酶抑制剂家族中定义了一个新的亚组。Cys蛋白缺乏半胱氨酸蛋白酶抑制剂抑制C1半胱氨酸蛋白酶所必需的三个共识位点中的两个。它们也优先在减数分裂生殖细胞、附睾近端和垂体前叶促性腺激素表达。因此，CRES蛋白可以在生殖和神经内分泌系统中发挥独特的和组织特异性的功能。作为CYS亚家族的成员，半胱氨酸蛋白酶抑制剂8是在附睾的近端头区域中表达的142个氨基酸的蛋白质，在精子发育和成熟过程中它起着特殊的作用。