FITC标记的代谢型谷氨酸受体5B抗体
产品名称： FITC标记的代谢型谷氨酸受体5B抗体
英文名称： Anti-MGLUR5/FITC
产品编号： HZ-18801R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MGLUR5/FITC Conjugated antibody
FITC标记的代谢型谷氨酸受体5B抗体
| 英文名称 | Anti-MGLUR5/FITC |
| 中文名称 | FITC标记的代谢型谷氨酸受体5B抗体 |
| 别 名 | MGLUR5B; Glutamate receptor metabotropic 5; GPRC1E; GRM 5; GRM5; Metabotropic glutamate receptor 5; mGlu5; mGluR5; mGluR5a; mGluR5b; Metabotropic glutamate receptor 5 variant F; Metabotropic Glutamate Receptor 5b; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate receptor 5 variant H; PPP1R86; GRM5_HUMAN; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Horse, Sheep, Monkey, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 130kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MGLUR5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals. Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Subunit: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity). Subcellular Location: Cell Membrane Similarity: Belongs to the G-protein coupled receptor 3 family. Database links: Entrez Gene: 2915 Human Entrez Gene: 108071 Mouse Entrez Gene: 24418 Rat Omim: 604102 Human SwissProt: P41594 Human SwissProt: Q3UVX5 Mouse SwissProt: P31424 Rat Unigene: 147361 Human Unigene: 29972 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
谷氨酸受体是脑内主要的兴奋性神经递质受体。谷氨酸受体存在两类：离子型受体和代谢型受体（MGLURS）。代谢型谷氨酸受体5b(GRM5)活性由G蛋白介导，G蛋白激活磷脂酰肌醇-钙第二信使系统并产生钙激活的氯电流。代谢型谷氨酸受体5型(mGlu5)表达于两种剪接变异体，即mGlu5 a和mGlu5b，不同之处在于mGlu5b在细胞内C端区域具有33个氨基酸插入。这种受体亚型是高度调节的，在发育中的动物中发现更高的水平。