PTEN purified MaxPab mouse polyclonal antibody (B02P)
产品名称： PTEN purified MaxPab mouse polyclonal antibody (B02P)
英文名称： PTEN purified MaxPab mouse polyclonal antibody (B02P)
产品编号： H00005728-B02P
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human PTEN protein.
- Immunogen:
- PTEN (NP_000305.3, 1 a.a. ~ 403 a.a) full-length human protein.
- Sequence:
- MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- PTEN MaxPab polyclonal antibody. Western Blot analysis of PTEN expression in HeLa.
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of PTEN expression in transfected 293T cell line (H00005728-T02) by PTEN MaxPab polyclonal antibody.
Lane 1: PTEN transfected lysate(44.33 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 5728
- GeneBank Accession#:
- NM_000314.4
- Protein Accession#:
- NP_000305.3
- Gene Name:
- PTEN
- Gene Alias:
- 10q23del,BZS,MGC11227,MHAM,MMAC1,PTEN1,TEP1
- Gene Description:
- phosphatase and tensin homolog
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
- Other Designations:
- MMAC1 phosphatase and tensin homolog deleted on chromosome 10,OTTHUMP00000020032,mutated in multiple advanced cancers 1
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Alzheimer Disease
- Alzheimer disease
- Astrocytoma
- Autistic Disorder
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Endometrioid
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Craniofacial Abnormalities