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上海信裕生物科技有限公司
TWIST2抗体

TWIST2抗体

商家询价

产品名称： TWIST2抗体

英文名称： TWIST2Antibody

产品编号： XY11752-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 TWIST2抗体Applications

In-house applications ELISA, WB     Application not tested? Please see our Guarantee.
Species specificity Human, Mouse; other species not tested.
Images
Prev1NextView more validation data
  • 11752-1-AP;NIH/3T3 cellsNIH/3T3 cells were subjected to SDS PAGE followed by western blot with 11752-1-AP(TWIST2 antibody) at dilution of 1:500
Positive WB detected in NIH/3T3 cells, MCF7 cells, mouse liver tissue
Recommended dilution WB : 1:200-1:2000
 TWIST2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information TWIST2抗体
Immunogen TWIST2 fusion protein ag2348 Full name Twist homolog 2 (Drosophila)
Calculated molecular
weight		 160aa,18 kDa Observed molecular 
weight		 21kDa, 60 kDa
GenBank accession 
number		 BC033168 Gene ID (NCBI) 117581
Gene symbol TWIST2 Synonyms BHLHa39, Dermis expressed protein 1, Dermo 1, DERMO1, twist homolog 2 (Drosophila), Twist related protein 2, TWIST2
Background

TWIST2, also named as BHLHA39 and DERMO1,is a basic helix-loop-helix protein which acts as a transcriptional regulator, plays a central role in differentiation of mesodermal during embryogenesis. TWIST2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. It is also implicated in tumorigenesis, invasion and metastasis. TWIST2 forms both homodimers(45KD) and heterodimers with E2A E proteins, and dimer partner selection is a critical mediator of TWIST function. (PMID:14724576, 16502419). The protein sequence of TWIST1 and TWIST2 is very similar. This antibody can recognize both TWIST1(~28kd), TWIST2 (22kd) and the Dimer form (45-60kd). TWIST2抗体

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