FITC标记的磷酸化桩蛋白Paxillin抗体
产品名称： FITC标记的磷酸化桩蛋白Paxillin抗体
英文名称： Anti-Phospho-Paxillin (Tyr118)/FITC
产品编号： HZ-3352R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-Paxillin (Tyr118)/FITC Conjugated antibody
FITC标记的磷酸化桩蛋白Paxillin抗体
| 英文名称 | Anti-Phospho-Paxillin (Tyr118)/FITC |
| 中文名称 | FITC标记的磷酸化桩蛋白Paxillin抗体 |
| 别 名 | p-paxillin; p-PXN(Y118); p-PXN(Tyr118); Paxillin (phospho Y118); Paxillin (phospho Tyr118); p-Paxillin (Tyr118); Paired box protein Pax 1; PAX 1; PAX1; Paxillin alpha; PXN; PXN protein; FLJ16691; FLJ23042; FLJ16691; PAXI_HUMAN; Paxillin; PXN protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 68kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Paxillin around the phosphorylation site of Tyr118 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk). Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Subunit: Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Subcellular Location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery. Post-translational modifications: Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Similarity: Belongs to the paxillin family. Contains 4 LIM zinc-binding domains. Database links: Entrez Gene: 5829 Human Entrez Gene: 19303 Mouse Entrez Gene: 360820 Rat Omim: 602505 Human SwissProt: P49023 Human SwissProt: Q8VI36 Mouse SwissProt: Q66H76 Rat Unigene: 446336 Human Unigene: 18714 Mouse Unigene: 75 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Paxillin是一种分子量为68KDa的局部粘附蛋白，参与肿瘤细胞的粘附与转移。主要用于各种恶性肿瘤的研究。 Paxillin 蛋白是胞外基质细胞粘附（粘着斑）位点上肌动蛋白-膜附着的细胞骨架蛋白。 Paxillin 在整合蛋白的信号传导中起着非常重要的作用，整合蛋白介导的细胞骨架的再组织需要，paxillin 酪氨酸残基的磷酸化。 Paxillin 被粘着斑激酶 (FAK)在其118位的酪氨酸残基处磷酸化。已经证明，paxillin 118位和31位两个酪氨酸的磷酸化对于MM1癌细胞的迁移是重要的 |
帕西林是一个64 kDa的细胞骨架适配器蛋白参与组织粘连和功能，这是至关重要的细胞粘附和迁移。这反过来在各种各样的过程中起作用，包括胚胎发生、器官发生、创伤修复、炎症和癌症。Paxillin包含LD基序、LIM结构域、SH3和SH2结合域，它们作为细胞骨架蛋白的对接位点，tyrosine kinases（例如FAK、PYK 2、SRC）、丝氨酸/苏氨酸激酶、GTPASE激活蛋白和其他适配器蛋白（例如肌动蛋白、纽蛋白、CRK）。