Nova2,神经肿瘤Nova2抗原抗体

产品编号HZ-11325R
英文名称Nova2
中文名称神经肿瘤Nova2抗原抗体
别 名ANOVA; Astrocytic NOVA1 like RNA binding protein; Gm1424; NOVA2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞类型标志物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Rabbit,
Nova2,神经肿瘤Nova2抗原抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Nova2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Nova2,神经肿瘤Nova2抗原抗体PubMedPubMed
产品介绍background:
Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

Function:
NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It binds single strand RNA.

Subunit:
Interacts with PTBP2; the interaction is direct (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain. Expression restricted to astrocytes.

Nova2,神经肿瘤Nova2抗原抗体Similarity:
Contains 3 KH domains.

Database links:
UniProtKB/Swiss-Prot: Q9UNW9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.