分子量:33.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human MICA, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human MICA, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 33.6 kDa. The predicted N-terminus is Glu 24. The reducing (R) protein migrates as 45-65 kDa in SDS-PAGE  due to glycosylation.

产品背景:MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.