FITC标记的G蛋白信号传导激活蛋白1抗体
产品名称： FITC标记的G蛋白信号传导激活蛋白1抗体
英文名称： Anti-Dexras1/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Dexras1/FITC Conjugated antibody
FITC标记的G蛋白信号传导激活蛋白1抗体
| 英文名称 | Anti-Dexras1/FITC |
| 中文名称 | FITC标记的G蛋白信号传导激活蛋白1抗体 |
| 别 名 | Activator of G protein signaling 1; Activator of G protein signaling; Activator of G-protein signaling 1; AGS 1; AGS1; Dexamethasone induced ras related protein 1; Dexamethasone-induced ras protein 1; Dexamethasone-induced Ras-related protein 1; Dexras 1; MGC:26290; RAS dexamethasone induced 1; Ras protein, Dexamethasone-induced, 1; Ras related protein; RASD 1; Rasd1; RASD1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 细胞分化 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dexras1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011] Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65. Subcellular Location: Cell membrane. Cytoplasm > perinuclear region. Nucleus. Tissue Specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues. Post-translational modifications: S-nitrosylation stimulates guanine-nucleotide exchange activity. Similarity: Belongs to the small GTPase superfamily. RasD family. Database links: Entrez Gene: 51655 Human Entrez Gene: 19416 Mouse Omim: 605550 Human SwissProt: Q9Y272 Human SwissProt: O35626 Mouse Unigene: 25829 Human Unigene: 3903 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码小GTP酶的RAS超家族成员，并由诱导。编码的蛋白是G-蛋白信号的激活剂，作为Gi-Go蛋白的直接核苷酸交换因子。该蛋白与神经元一氧化氮适配子蛋白CAPON和核适配子蛋白FE65相互作用，后者与阿尔茨海默病淀粉样前体蛋白相互作用。该基因可能在诱导的细胞形态、生长和细胞外基质相互作用的改变中发挥作用。该基因的表观遗传失活与多发性骨髓瘤细胞中的耐药密切相关。另一种编码不同的异构体的剪接转录变体已被发现用于该基因。