CASR polyclonal antibody
产品名称： CASR polyclonal antibody
英文名称： CASR polyclonal antibody
产品编号： PAB18311
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CASR.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding T888 of human CASR.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to CASR.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.
Huang Y, Niwa J, Sobue G, Breitwieser GE.J Biol Chem. 2006 Apr 28;281(17):11610-7. Epub 2006 Mar 2.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from LoVo cells, using CASR polyclonal antibody (Cat # PAB18311).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 846
- Protein Accession#:
- P41180
- Gene Name:
- CASR
- Gene Alias:
- CAR,FHH,FIH,GPRC2A,HHC,HHC1,MGC138441,NSHPT,PCAR1
- Gene Description:
- calcium-sensing receptor
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq
- Other Designations:
- extracellular calcium-sensing receptor,parathyroid Ca(2+)-sensing receptor 1
- Related Disease
- Adenoma
- Alzheimer Disease
- Alzheimer disease
- Aortic Valve Stenosis
- Atherosclerosis
- Birth Weight
- Body Weight
- Calcinosis
- Calcium Metabolism Disorders
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Progression