FITC标记的20号染色体开放阅读框20抗体
产品名称： FITC标记的20号染色体开放阅读框20抗体
英文名称： Anti-C20orf20/FITC
产品编号： HZ-15104R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C20orf20/FITC Conjugated antibody
FITC标记的20号染色体开放阅读框20抗体
| 英文名称 | Anti-C20orf20/FITC |
| 中文名称 | FITC标记的20号染色体开放阅读框20抗体 |
| 别 名 | C20orf20; Chromosome 20 open reading frame 20; Eaf7; FLJ10914; MRG (MORF4 related gene) binding protein; MRG binding protein; MRG-binding protein; MRG/MORF4L binding protein; MRG15BP; MRGBP; MRGBP_HUMAN; OTTHUMP00000031512; URCC4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C20orf20 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Proteins expressed in the endoplasmic reticulum (ER) are tightly regulated by a variety of quality control mechanisms. Terminally misfolded proteins in the ER are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM2 (ER degradation-enhancing alpha-mannosidase-like 2) is a 578 amino acid secreted protein that, in conjunction with other EDEM proteins (namely EDEM and EDEM3), is involved in the ERAD pathway of protein degradation. EDEM2, a member of the glycosyl hydrolase 47 family, contains a mannosidase homology domain, an N-terminal cleavable signal sequence and a C-terminal extension that is required for both ER retention and the proper function of EDEM2. Human EDEM2 shares 93% sequence identity with its mouse homolog, suggesting a conserved role between species. Two isoforms of EDEM2 exist due to alternative splicing events. Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX. Subcellular Location: Nucleus. Similarity: Belongs to the EAF7 family. Database links: Entrez Gene: 55257 Human Entrez Gene: 73247 Mouse Omim: 611157 Human SwissProt: Q9NV56 Human SwissProt: Q9DAT2 Mouse Unigene: 590870 Human Unigene: 426558 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
内质网（ER）中表达的蛋白质受到多种质量控制机制的严格调控。ER中最终错误折叠的蛋白质通过ER相关降解（ERAD）的机制被反转运到细胞质并由蛋白酶体降解。EDEM2(ER降解增强型α-甘露糖苷酶样2)是578个氨基酸分泌的蛋白质，与其他EDEM蛋白(即EDEM和EDEM3)一起参与蛋白质降解的ERAD途径。EDEM2是糖基水解酶47家族的成员，包含甘露糖苷酶同源结构域、N端可裂解信号序列和C端延伸，这些是ER保留和EDEM2正常功能所必需的。人EdEM2与小鼠同源物共有93%个序列同一性，提示物种间具有保守的作用。EdEM2的两种异构体由于选择性剪接事件而存在。