FITC标记的抑癌蛋白DKK1抗体
产品名称： FITC标记的抑癌蛋白DKK1抗体
英文名称： Anti-DKK1/FITC
产品编号： HZ-2162R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DKK1/FITC Conjugated antibody
FITC标记的抑癌蛋白DKK1抗体
| 英文名称 | Anti-DKK1/FITC |
| 中文名称 | FITC标记的抑癌蛋白DKK1抗体 |
| 别 名 | Dickkopf 1; Dickkopf 1 like; Dickkopf homolog 1; Dickkopf related protein 1; DKK 1; hDkk 1; hDkk1; DKK-1; SK. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DKK1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008] Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Subcellular Location: Secreted. Tissue Specificity: Placenta. Similarity: Belongs to the dickkopf family. Database links: Entrez Gene: 22943 Human Entrez Gene: 13380 Mouse Entrez Gene: 293897 Rat Omim: 605189 Human SwissProt: O94907 Human SwissProt: O54908 Mouse Unigene: 40499 Human Unigene: 214717 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DKK1是一种分泌蛋白，也是Wnt信号途径的一个抑制蛋白，在多种恶性肿瘤细胞系中高度表达，在肿瘤的发生、发展中有重要作用. |
该基因编码的蛋白质是Dikkopf家族的成员。它是一种分泌蛋白，含有两个富含半胱氨酸的区域，通过抑制Wnt信号通路参与胚胎发育。骨髓和外周血中DKK1水平升高与多发性骨髓瘤患者溶骨性骨损害的发生有关。[ RefSeq，JUL 2008 ]