MAP3K7 (phospho S192) polyclonal antibody
产品名称： MAP3K7 (phospho S192) polyclonal antibody
英文名称： MAP3K7 (phospho S192) polyclonal antibody
产品编号： PAB0516
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP3K7.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S192 of human MAP3K7.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Wnt activates the Tak1/Nemo-like kinase pathway.
Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H.J Biol Chem. 2004 Apr 23;279(17):17232-40. Epub 2004 Feb 11.
- 2.
- A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta.
Ono K, Ohtomo T, Ninomiya-Tsuji J, Tsuchiya M.Biochem Biophys Res Commun. 2003 Jul 25;307(2):332-7.
- 3.
- Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T, Saiki I.J Biol Chem. 2003 Sep 19;278(38):36916-23. Epub 2003 Jul 3.
- Applications
- Dot Blot (Peptide)
- Dot blot analysis of MAP3K7 (phospho S192) polyclonal antibody (Cat # PAB0516) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 ug/mL. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide.
- Entrez GeneID:
- 6885
- Protein Accession#:
- NP_003179;O43318
- Gene Name:
- MAP3K7
- Gene Alias:
- TAK1,TGF1a
- Gene Description:
- mitogen-activated protein kinase kinase kinase 7
- Omim ID:
- 602614
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016870,OTTHUMP00000016871,OTTHUMP00000016872,OTTHUMP00000016873,TGF-beta activated kinase 1,transforming growth factor-beta-activated kinase 1
- Interactome
