FITC标记的Iroquois同源蛋白4抗体
产品名称： FITC标记的Iroquois同源蛋白4抗体
英文名称： Anti-IRX4/FITC
产品编号： HZ-9464R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IRX4/FITC Conjugated antibody
FITC标记的Iroquois同源蛋白4抗体
| 产品编号 | bs-9464R-FITC |
| 英文名称 | Anti-IRX4/FITC |
| 中文名称 | FITC标记的Iroquois同源蛋白4抗体 |
| 别 名 | Homeodomain protein IRXA3; Iroquois Homeobox Protein 4; Iroquois-class homeodomain protein IRX-4; Iroquoisclass homeodomain protein IRX4; Irx4; IRX4_HUMAN; IRXA3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 发育生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IRX4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4; the IRXB group is comprised of Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5–E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal, and Irx5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4(-) mice appears to develop normally, adult Irx4(-) mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility. Function: Likely to be an important mediator of ventricular differentiation during cardiac development. Subcellular Location: Nucleus. Tissue Specificity: Predominantly expressed in cardiac ventricles. Similarity: Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 50805 Human Entrez Gene: 50916 Mouse Entrez Gene: 306655 Rat Omim: 606199 Human SwissProt: P78413 Human SwissProt: Q2NL64 Human SwissProt: A0JNT5 Mouse SwissProt: Q3V1B6 Mouse SwissProt: Q9QY61 Mouse Unigene: 196927 Human Unigene: 103784 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IROQUOIS同源盒基因家族的转录因子调节胚胎发育的各个方面，包括中枢神经系统中的前/后和背/腹轴构图。Iroquois家族聚集在两个位点，IrxA和IrxB，它们映射到小鼠的染色体8和13。IrxA组包括Irx1、Irx2和Irx4；IrxB组由Irx3、Irx5和Irx6组成。Irx1和Irx2在肺上皮和心室中隔的发育过程中都有广泛的表达。Irx1和Irx2也在数字形成中起作用（E11.5～E14.5）。Irx gene家族成员在小鼠心脏发育过程中均以不同的模式表达。具体而言，Irx1和Irx2在室间隔中表达，Irx3在心室小梁心肌中表达。此外，Irx4在线性心脏管和AV管中表达，Irx5在心室内膜和心房肌内膜内层中表达。此外，Irx4基因可能调节心脏的发育和功能。虽然Irx4（-）小鼠的心脏似乎正常发育，但成年Irx4（-）小鼠表现出心肌病，包括心肌肥大和收缩力降低。