Toll样受体信号通路ChIP qPCR芯片(Toll-Like Receptor Signaling Pathway EpiTect CHIP qPCR Ar
产品名称： Toll样受体信号通路ChIP qPCR芯片(Toll-Like Receptor Signaling Pathway EpiTect CHIP qPCR Ar
英文名称： Toll-Like Receptor Signaling Pathway EpiTect CHIP qPCR Array
产品编号： yb256
产品价格： 4800
产品产地： null
品牌商标： null
更新时间： null
使用范围： null
- 联系人 : 谷小姐
- 地址 : 上海市闵行区浦江镇联航路1239弄8B号3楼
- 邮编 : 201112
- 所在区域 : 上海
- 电话 : 181****9791 点击查看
- 传真 : 点击查看
- 邮箱 : gulingzhi@yingbio.com
|
EpiTect ChIP qPCR Array |
|
Product |
Species |
Technology |
Cat. No. |
|
Toll-Like Receptor Signaling Pathway EpiTect ChIP qPCR Array |
Human |
||
|
Toll-Like Receptor Signaling Pathway EpiTect ChIP qPCR Array |
Mouse |
Toll样受体信号通路ChIP qPCR芯片分析TLR介导的信号转导和先天免疫相关的48个关键基因的组蛋白修饰状态或组蛋白密码。组蛋白修饰调节染色质结构和与相关基因的转录活性。模式识别受体的TLR家族(PRRs)通过病原体相关分子模式(PAMPs)识别广泛的病原体：细菌、病毒、真菌和寄生虫。每个受体结合特定配体，启动一个特定的先天免疫反应，应答特定种类的病原体，并激活适应性免疫反应。例如，TLR4识别细菌脂多糖(LPS)或内毒素,该复合，导致血源性感染期间发生感染性休克。受体以单体形式或异二聚体形式与适配器蛋白相互作用，启动MyD88或TICAM1(TRIF)端依赖性反应。这些反应主要是通过NFκB分子激发信号级联反应。NFκB能够激活下游的JNK/p38信号或细胞因子分泌。这些信号通路的失活会导致严重的后果，并且引起多种自身免疫性疾病和病理性的炎症。这款芯片包含了TLR信号分子家族、受体、效应分子、以及受TLR激活的下游信号通路中的关键基因。这些下游信号通路包括：NFκB、JNK/p38、IRF 和JAK/STAT信号通路。分析这些基因的组蛋白修饰有助于确定调控增强先天免疫反应能力的系统的表观遗传机制。通过染色质免疫沉淀和EpiTect ChIP qPCR芯片，可以很简易、可靠地分析组蛋白修饰和TLR介导的信号传导通路相关基因的关联。
Toll-Like Receptors:CD180 (LY64), SIGIRR, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10.
Pathogen-Specific Responses:
Bacterial:CCL2 (MCP-1), CD14, CD180 (LY64), FOS, HRAS, IL10, IL12A, IL1B, IL6, IL8, IRAK1, HMGB1, JUN, LTA (TNFB), LY86 (MD-1), LY96, NFKBIA (IKBA/MAD3), PTGS2 (COX2), RELA, RIPK2, TLR2, TLR4, TLR6, TNFRSF1A, TICAM1 (TRIF).
Viral:EIF2AK2 (PRKR), IFNB1, IFNG, IL12A, IL6, IRF3, PRKRA, RELA, TBK1, TLR3, TLR7, TLR8, TNF, TICAM1 (TRIF).
Fungal/Parasitic:CLEC4E, HRAS, IL8, TLR2, TIRAP.
TLR Signaling:
Negative Regulation:SARM1, SIGIRR, TOLLIP.
TICAM1 (TRIF)-Dependent (MYD88-Independent):IRF3, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), NR2C2, PELI1, TBK1, TICAM2, TLR3, TLR4, TRAF6, TICAM1 (TRIF).
MYD88-Dependent:IRAK1, IRAK2, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), MYD88, NR2C2, TIRAP, TLR1, TLR10, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TRAF6.
Downstream Pathways and Target Genes:
NF?B Pathway:BTK, CASP8, CHUK (IKKa), ECSIT (SITPEC), FADD, IKBKB, IL10, IL1B, IRAK1, IRAK2, IRF3, LY96, MAP3K7, MAP4K4, NFKB1, NFKB2, NFKBIA (IKBA/MAD3), NFKBIB, NFKBIL1, NFRKB, PPARA, REL, RELA, TNF, TNFRSF1A, UBE2N, UBE2V1.
JNK/p38 Pathway:ELK1, FOS, IL1B, JUN, MAP2K3 (MEK3), MAP2K4 (JNKK1), MAP3K7, MAPK8 (JNK1), MAPK8IP3, MAPK9, TNF.
JAK/STAT Pathway:CCL2 (MCP-1), CSF2 (GM-CSF), IFNG, IL12A, IL2, IL6.
Interferon Regulatory Factor (IRF) Pathway:CXCL10 (INP10), IFNA1, IFNB1, IFNG, IRF1, IRF3, TBK1.
Cytokine-Mediated Signaling Pathway:CCL2 (MCP-1), CSF3 (GCSF), IL1A, IL1B, IL6, IRAK1, IRAK2, RELA, SIGIRR, TNF, TNFRSF1A.
Regulation of Adaptive Immunity:CD80, CD86, HSPD1, IFNG, IL10, IL12A, IL1B, IL2, MAP3K7, TRAF6.
Adaptors & TLR Interacting Proteins:BTK, CD14, HMGB1, HRAS, HSPD1, LY86 (MD-1), LY96 (MD-2), MAPK8IP3, MYD88, PELI1, RIPK2, SARM1, TICAM1 (TRIF), TICAM2 (TRAM), TIRAP, TOLLIP.
Effectors:CASP8 (FLICE), EIF2AK2 (PRKR), FADD, IRAK1, IRAK2, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), NR2C2, PPARA, PRKRA, ECSIT (SITPEC), TRAF6, UBE2N, UBE2V1.