FITC标记的睫状神经根卷曲螺旋蛋白抗体
产品名称： FITC标记的睫状神经根卷曲螺旋蛋白抗体
英文名称： Anti-CROCC/FITC
产品编号： HZ-14066R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CROCC/FITC Conjugated antibody
FITC标记的睫状神经根卷曲螺旋蛋白抗体
| 英文名称 | Anti-CROCC/FITC |
| 中文名称 | FITC标记的睫状神经根卷曲螺旋蛋白抗体 |
| 别 名 | ciliary rootlet coiled coil; Ciliary rootlet coiled-coil protein; Crocc; CROCC_HUMAN; KIAA0445; Rootletin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 228kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CROCC |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CROCC is a 2017 amino acid protein that forms centriole-associated fibrous structures and is an essential component of the ciliary rootlet. Localized to basal bodies and centrosomes in ciliated and nonciliated cells, respectively, Rootletin associates with the proximal ends of basal bodies and, in photoreceptors, functions to form elongated polymers between them. Rootletin is required for centrosome cohesion and, through interaction with C-Nap1 (a centrosomal protein present at the ends of the centrioles), can regulate the linkage of centrioles to basal bodies. Rootletin exists as a homopolymer whose association with centrosomes can be regulated via phosphorylation by Nek2 (NIMA-related kinase 2). Two isoforms exist due to alternative splicing events. Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis. Post-translational modifications: Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Cytoplasm; cytoskeleton; centrosome; centriole. In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. Similarity: Belongs to the rootletin family. Database links: Entrez Gene: 9696 Human SwissProt: Q5TZA2 Human Unigene: 309403 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CROCC是一种2017氨基酸蛋白，形成中心粒相关的纤维结构，是睫状根的重要组成部分。根瘤菌素分别定位于纤毛细胞和非纤毛细胞中的基底体和中心体，与基底体的近端结合，在光感受器中，在纤毛体和非纤毛细胞之间形成伸长的聚合物。根瘤素是中心体内聚所必需的，并且通过与C-Nap1（存在于中心粒末端的中心体蛋白）的相互作用，可以调节中心粒与基础体的连接。根瘤素作为均聚物存在，其与中心体的结合可以通过Nek2（NIMA相关激酶2）的磷酸化来调节。两种异构体由于选择性剪接事件而存在。