FITC标记的神经束蛋白186抗体
产品名称： FITC标记的神经束蛋白186抗体
英文名称： Anti-Nfasc186 /FITC
产品编号： HZ-11214R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Nfasc186 /FITC Conjugated antibody
FITC标记的神经束蛋白186抗体
| 产品编号 | bs-11214R-FITC |
| 英文名称 | Anti-Nfasc186 /FITC |
| 中文名称 | FITC标记的神经束蛋白186抗体 |
| 别 名 | Neurofascin; NF antibody NF186; NFASC; NRCAML; NFASC_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 147kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nfasc186 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nfasc186 (Neurofascin 186) is one of two alternatively spliced products of the Neurofascin (Nfasc) gene in rat; the other being Nfasc155. The establishment of paranodal axoglial junctions in myelinated nerves where voltage-gated sodium channels are concentrated at the nodes of Ranvier is determined by myelin-forming glia. The two isoforms of Neurofascin, Nfasc186 in neurons and Nfasc155 in glia, are required for the assembly of these specialized domains. These two major Neurofascins play essential roles in assembling the nodal and paranodal domains of myelinated axons and are essential for the transition to saltatory conduction in developing vertebrate nerves. Nfasc186 (Isoform 1) is expressed at the Nodes of Ranvier while the Nfasc155 (isoforms 2 and 3) are expressed in unmyelinated axons. Function: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions (By similarity). Subunit: Horseshoe-shaped homodimer. Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin (By similarity). Subcellular Location: Cell Membrane; Type I membrane protein. Similarity: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. Contains 5 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains. Database links: UniProtKB/Swiss-Prot: O94856.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NFASC186（神经纤维蛋白186）是大鼠神经丝蛋白（NFASC）基因的两种剪接产物之一，另一种是NFASC155。电压依赖性钠通道集中在RANVER淋巴结的有髓神经的旁轴突轴突结点的建立是由髓鞘形成的胶质细胞决定的。Neurofascin、NFASC186和胶质细胞中NASFC155的两种亚型是这些特殊结构域的组装所必需的。这两个主要的神经突起在组装有髓鞘轴突的节和旁结构域中起着至关重要的作用，并且对于发展脊椎动物神经的跳跃性传导是必不可少的。NFASC186（异构体1）在RANVER的节点上表达，而NFASC155（异构体2和3）在无髓鞘轴突中表达。