FITC标记的胆碱酯酶抑制剂8抗体
产品名称： FITC标记的胆碱酯酶抑制剂8抗体
英文名称： Anti-RIC8A/FITC
产品编号： HZ-11355R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RIC8A/FITC Conjugated antibody
FITC标记的胆碱酯酶抑制剂8抗体
| 产品编号 | bs-11355R-FITC |
| 英文名称 | Anti-RIC8A/FITC |
| 中文名称 | FITC标记的胆碱酯酶抑制剂8抗体 |
| 别 名 | Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); RIC8; RIC8A; RIC8A_HUMAN; synembryn; Synembryn-A; MGC104517; MGC131931; MGC148073; MGC148074. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RIC8A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: The Ras superfamily of GTPases can be subdivided into the Ras, Rho/Rac, Sar, Rab, Arf, Rap and Ran subfamilies, all of which control multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). RIC-8A (resistance to inhibitors of cholinesterase 8 homolog A), also known as RIC8 or Synembryn-A, is a 530 amino acid cytoplasmic protein that can activate several G-alpha proteins, including G?i-1, G?q and G?o. Functioning as a guanine nucleotide exchange factor, RIC-8A binds to GDP-associated substrates and exchanges bound GDP for free GTP. Via its ability to stimulate protein function, RIC-8A plays a role in regulating mitotic movement and may be involved in receptor-mediated ERK activation. RIC-8A is expressed as three isoforms due to alternative splicing events. Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. Subunit: Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity). Subcellular Location: Cytoplasm. Cell membrane. Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the synembryn family. Database links: Entrez Gene: 60626 Human Omim: 609146 Human SwissProt: Q9NPQ8 Human Unigene: 592292 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GTPs的Ras超家族可分为RAS、Rho／Rac、Sar、RAB、ARF、RAP和RAN亚家族，它们均控制细胞功能的多个方面，包括细胞骨架重排、核信号传导和细胞生长。GTPASS的RAS超家族作为调节开关，在生物活性的GTP结合和非活性的GDP结合形式之间切换。这种激活是由鸟嘌呤核苷酸交换因子（GEFs）催化的。RIC-8A（抗胆碱酯酶8同系物A抑制剂），也称为RIC8或SyBuryN-A，是530个氨基酸胞质蛋白，能激活多种Gα蛋白，包括G？I-1，G？Q和G？作为一种鸟嘌呤核苷酸交换因子，RIC-8A与GDP相关底物结合，交换游离GTP的GDP。RIC-8A通过其刺激蛋白质功能的能力在调节有丝分裂运动中起作用，并且可能参与受体介导的ERK激活。由于选择性剪接事件，RIC-8A被表达为三种异构体。