FITC标记的磷酸化蛋白激酶PKMYT1(Thr495)抗体
产品名称： FITC标记的磷酸化蛋白激酶PKMYT1(Thr495)抗体
英文名称： Anti-phospho-PKMYT1 (Thr495)/FITC
产品编号： HZ-5531R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-PKMYT1 (Thr495)/FITC Conjugated antibody
FITC标记的磷酸化蛋白激酶PKMYT1(Thr495)抗体
| 英文名称 | Anti-phospho-PKMYT1 (Thr495)/FITC |
| 中文名称 | FITC标记的磷酸化蛋白激酶PKMYT1(Thr495)抗体 |
| 别 名 | PKMYT1(phospho T495);cdc2 inhibitory kinase; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT 1; Pkmyt1; PMYT1_HUMAN; Protein kinase membrane associated tyrosine/threonine 1; Protein kinase Myt1; DKFZp547K1610; FLJ20093. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 免疫学 信号转导 细胞周期蛋白 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human PKMYT1 around the phosphorylation site of Thr495 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Subunit: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1. Subcellular Location: Endoplasmic reticulum membrane. Golgi apparatus membrane. Post-translational modifications: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 9088 Human Entrez Gene: 268930 Mouse Entrez Gene: 287101 Rat Omim: 602474 Human SwissProt: Q99640 Human SwissProt: Q9ESG9 Mouse Unigene: 77783 Human Unigene: 182193 Mouse Unigene: 204349 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码丝氨酸/苏氨酸蛋白激酶家族的成员。编码的蛋白是膜相关激酶，通过磷酸化和失活细胞周期蛋白依赖性激酶1，负调控细胞周期的G2/M跃迁。编码蛋白的活性受POLO样激酶1调节。另一种编码多个异构体的剪接转录变体已被观察到该基因。[ RefSeq，2012年5月提供]