FITC标记的细胞内流钾通道蛋白Kir5.1抗体
产品名称： FITC标记的细胞内流钾通道蛋白Kir5.1抗体
英文名称： Anti-KIR5.1/FITC
产品编号： HZ-12179R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KIR5.1/FITC Conjugated antibody
FITC标记的细胞内流钾通道蛋白Kir5.1抗体
| 英文名称 | Anti-KIR5.1/FITC |
| 中文名称 | FITC标记的细胞内流钾通道蛋白Kir5.1抗体 |
| 别 名 | 6430410F18Rik; AI132396; BIR9; Inward rectifier K channel Kir5.1; Inward rectifier K(+) channel Kir5.1; Inward rectifier potassium channel 16; IRK16; IRKG; KCNJ16; MGC33717; Potassium channel inwardly rectifying subfamily J member 16; Potassium inwardly rectifying channel subfamily J member 16; RP23-218O16.1; IRK16_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KIR5.1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The KIR family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role in the pathogenesis of Down’s syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17. Function: KIR5.1 is one of 20 members of the inwardly rectifying potassium (Kir) channel family. Due to its expression in kidney, pancreas and thyroid gland, it has been suggested that human KIR5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease. Subunit: Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2. Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Highly expressed in kidney, pancreas and thyroid gland. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. Database links: Entrez Gene: 3773 Human Entrez Gene: 16517 Mouse Entrez Gene: 29719 Rat Omim: 605722 Human SwissProt: Q9NPI9 Human SwissProt: Q9Z307 Mouse SwissProt: P52191 Rat Unigene: 463985 Human Unigene: 1989 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
钾通道的KIR家族具有更大的倾向，允许钾进入细胞而不是流出细胞。KIL4.1，也被称为KIL1.2，在脑中高表达，包括神经胶质细胞、星形胶质细胞和皮层神经元。KIL4.1还表达在髓鞘合成少突胶质细胞中，在发育中的神经系统中对髓鞘形成至关重要。编码人类KiR4.1的基因映射到第1号染色体。KIL4.2，也被称为KI1.3，在肾脏、肺、心脏、胸腺和甲状腺发育过程中表达。编码人Kir4.2的基因定位于唐氏综合征第1染色体区21号染色体，Kir4.2可能在唐氏综合征的发病机制中起作用。KIR 5.1仅在肾脏和胰腺中与KiR4.1或KiR4.2共同表达而形成功能通道。编码人类KIL5.1的基因映射到第17号染色体。