ACVR1 monoclonal antibody (M07), clone 2D5
产品名称: ACVR1 monoclonal antibody (M07), clone 2D5
英文名称: ACVR1 monoclonal antibody (M07), clone 2D5
产品编号: H00000090-M07
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant ACVR1.
- Immunogen:
- ACVR1 (AAH33867, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG1 Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
- MSDS:
- Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of ACVR1 expression in transfected 293T cell line by ACVR1 monoclonal antibody (M07), clone 2D5.
Lane 1: ACVR1 transfected lysate (Predicted MW: 57.2 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged ACVR1 is 0.03 ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 90
- GeneBank Accession#:
- BC033867
- Protein Accession#:
- AAH33867
- Gene Name:
- ACVR1
- Gene Alias:
- ACTRI,ACVR1A,ACVRLK2,ALK2,FOP,SKR1,TSRI
- Gene Description:
- activin A receptor, type I
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq
- Other Designations:
- TGF-B superfamily receptor type I,activin A receptor, type II-like kinase 2,activin A type I receptor,hydroxyalkyl-protein kinase,serine/threonine-protein kinase receptor R1
- Related Disease
- Abortion, Habitual
- Breast Neoplasms
- Genetic Predisposition to Disease
- Infertility, Female
- Intracranial Aneurysm
- Narcolepsy
- Neoplasms, Glandular and Epithelial
- Obesity
- Ovarian cancer
- Ovarian Failure, Premature
- Ovarian Neoplasms
- Polycystic Ovary Syndrome
- Prostate cancer
- Prostatic Neoplasms
- Puberty, Delayed
- Puberty, Precocious
- Stroke
- Thrombophilia
- Tobacco Use Disorder