HLA-E monoclonal antibody, clone MEM-E/06
产品名称: HLA-E monoclonal antibody, clone MEM-E/06
英文名称: HLA-E monoclonal antibody, clone MEM-E/06
产品编号: MAB3630
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant HLA-E.
- Immunogen:
- Recombinant protein corresponding to human HLA-E.
- Host:
- Mouse
- Reactivity:
- Human, Primates
- Specificity:
- This antibody recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results showed that This antibody cross-reacts with some classical MHC ClassI molecules (HLA-A3, -A11, -B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that This antibody exhibits much broader cross-reactivity classical MHC Class I antigens, namely with HLA-A24, -A32,-B8, -B15, -B27, -B35, -B44, -B54, -C3, -C4, -C5, -C7.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In TBS, pH 8.0 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.
Gonen-Gross T, Achdout H, Arnon TI, Gazit R, Stern N, Horejsi V, Goldman-Wohl D, Yagel S, Mandelboim O.J Immunol. 2005 Oct 15;175(8):4866-74.
- 2.
- HLA-E surface expression is independent of the availability of HLA class I signal sequence-derived peptides in human tumor cell lines.
Palmisano GL, Contardi E, Morabito A, Gargaglione V, Ferrara GB, Pistillo MP.Hum Immunol. 2005 Jan;66(1):1-12.
- 3.
- Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules.
Menier C, Saez B, Horejsi V, Martinozzi S, Krawice-Radanne I, Bruel S, Le Danff C, Reboul M, Hilgert I, Rabreau M, Larrad ML, Pla M, Carosella ED, Rouas-Freiss N.Hum Immunol. 2003 Mar;64(3):315-26.
- Application Image
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 3133
- Gene Name:
- HLA-E
- Gene Alias:
- DKFZp686P19218,EA1.2,EA2.1,HLA-6.2,MHC,QA1
- Gene Description:
- major histocompatibility complex, class I, E
- Omim ID:
- 143010
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq
- Other Designations:
- HLA class I histocompatibility antigen, E alpha chain,MHC HLA-E alpha-1,MHC HLA-E alpha-2.1,MHC class I antigen,OTTHUMP00000029214,lymphocyte antigen
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Acute Disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Bacterial Infections
- Behcet Syndrome
- Bone Marrow Diseases
- Carcinoma
- Chorioamnionitis
- Coronary Aneurysm
- Cytomegalovirus Infections
- Fetal Membranes, Premature Rupture
- Genetic Predisposition to Disease
- Graft vs Host Disease
- HIV Infections
- Lupus Erythematosus, Systemic
- Mucocutaneous Lymph Node Syndrome
- Nasopharyngeal Neoplasms