MMP2 polyclonal antibody
产品名称： MMP2 polyclonal antibody
英文名称： MMP2 polyclonal antibody
产品编号： PAB12382
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MMP2.
- Immunogen:
- A synthetic peptide corresponding to amino acids 475-490 of human MMP2.
- Sequence:
- MGPLLVATFWPELPEK
- Host:
- Rabbit
- Reactivity:
- Chicken, Human, Mouse, Rat
- Specificity:
- This antibody is specific to pro and active forms of MMP-2. It does not react with other MMPs tested.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.05% sodium azide)
- Storage Instruction:
- Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (Frozen sections) (2-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
Western Blot (1:1500-1:3500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- PEBP4 enhanced HCC827 cell proliferation and invasion ability and inhibited apoptosis.
Yu G, Shen Z, Chen G, Teng X, Hu Y, Huang B.Tumour Biol. 2012 Sep 15. [Epub ahead of print]
- 2.
- Effects of SASH1 on lung cancer cell proliferation, apoptosis, and invasion in vitro.
Chen EG, Chen Y, Dong LL, Zhang JS.Tumour Biol. 2012 Apr 10.
- 3.
- Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis.
Mikami S, Katsube KI, Oya M, Ishida M, Kosaka T, Mizuno R, Mukai M, Okada Y.Lab Invest. 2011 Aug 1. doi: 10.1038/labinvest.2011.111. [Epub ahead of print]
- 4.
- Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.
Horak CE, Lee JH, Elkahloun AG, Boissan M, Dumont S, Maga TK, Arnaud-Dabernat S, Palmieri D, Stetler-Stevenson WG, Lacombe ML, Meltzer PS, Steeg PS.Cancer Res. 2007 Aug 1;67(15):7238-46.
- 5.
- Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts.
Krekoski CA, Neubauer D, Graham JB, Muir D.J Neurosci. 2002 Dec 1;22(23):10408-15.
- 6.
- MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve.
Ferguson TA, Muir D.Mol Cell Neurosci. 2000 Aug;16(2):157-67.
- Applications
- Western Blot (Tissue lysate)
- Detection of MMP2 in a Western blot of recombinant MMP2 and injured rat nerve lysate using MMP2 polyclonal antibody (Cat # PAB12382).
- Western Blot (Recombinant protein)
- Western blot analysis of MMP2 on recombinant proteins using MMP2 polyclonal antibody (Cat # PAB12382). MMP2 polyclonal antibody (Cat # PAB12382) is specific for MMP2 (lane 5) and does not detect recombinant mouse MMP 3 (lane 1), MMP7 (lane 2), MMP9 (Lane 3) or MMP16 (lane 4).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Detection of MMP2 in a paraffin-embedded human neurofibroma section using MMP2 polyclonal antibody (Cat # PAB12382, 4 ug/mL).
- Entrez GeneID:
- 4313
- Protein Accession#:
- P08253
- Gene Name:
- MMP2
- Gene Alias:
- CLG4,CLG4A,MMP-II,MONA,TBE-1
- Gene Description:
- matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- collagenase type IV-A,matrix metalloproteinase 2,matrix metalloproteinase-II,neutrophil gelatinase
- Interactome
- Related Disease
- Acute Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Aortic Aneurysm, Abdominal
- Arthritis, Rheumatoid
- Atherosclerosis
- Atherosclerosis
- Atrial Fibrillation
- Breast cancer
- Breast Neoplasms
- Bronchopulmonary Dysplasia
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiac Output, Low