FITC标记的磷酸化果糖-2,6-二磷酸酶3/磷酸果糖激酶2抗体
产品名称： FITC标记的磷酸化果糖-2,6-二磷酸酶3/磷酸果糖激酶2抗体
英文名称： Anti-Phospho-PFKFB3/PFK2 (Ser467)/FITC
产品编号： HZ-3331R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-PFKFB3/PFK2 (Ser467)/FITC Conjugated antibody
FITC标记的磷酸化果糖-2,6-二磷酸酶3/磷酸果糖激酶2抗体
| 英文名称 | Anti-Phospho-PFKFB3/PFK2 (Ser467)/FITC |
| 中文名称 | FITC标记的磷酸化果糖-2,6-二磷酸酶3/磷酸果糖激酶2抗体 |
| 别 名 | 6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme; 6PF 2-K/Fru 2,6 P2ase 3; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase; iPFK 2; IPFK2; PFK/FBPase 3; PFK-2; PFK2; Renal carcinoma antigen NY REN 56; uPFK 2; PFKFB3; F263_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] Function: Synthesis and degradation of fructose 2,6-bisphosphate. Tissue Specificity: Ubiquitous. Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family. Database links: Entrez Gene: 5209 Human Entrez Gene: 170768 Mouse Entrez Gene: 24640 Rat Omim: 605319 Human SwissProt: Q16875 Human SwissProt: P25114 Rat Unigene: 444304 Human Unigene: 44844 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质属于双功能蛋白家族，参与了果糖-2，6-二磷酸的合成和降解，这是控制真核生物糖酵解的调节分子。编码的蛋白质具有6-磷酸果糖-2-激酶活性，催化果糖-2，6-二磷酸（F2，6BP）的合成，以及催化F2，6BP降解的果糖-2，6-双磷酸酶活性。这种蛋白质对细胞周期的进展和细胞凋亡的预防是必需的。它作为细胞周期蛋白依赖性激酶1的调节因子，将葡萄糖代谢与肿瘤细胞的增殖和存活联系起来。已经发现了几种编码不同亚型的交替剪接转录变体。[由RefSeq，APR 2016提供]