OGG1 Pre-design Chimera RNAi
产品名称： OGG1 Pre-design Chimera RNAi
英文名称： OGG1 Pre-design Chimera RNAi
产品编号： H00004968-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Homo sapiens 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_002542
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 4968
- Gene Name:
- OGG1
- Gene Alias:
- HMMH,HOGG1,MUTM,OGH1
- Gene Description:
- 8-oxoguanine DNA glycosylase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq
- Other Designations:
- 8-hydroxyguanine DNA glycosylase,OTTHUMP00000122619
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Adenoma
- Adenomatous Polyposis Coli
- Adenomatous Polyps
- Alzheimer Disease
- Alzheimer disease
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Angiomyolipoma
- Asbestosis
- Ataxia telangiectasia
- Atrophy
- Barrett Esophagus
- Biliary Tract Neoplasms
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Adenosquamous