Anti-FBXO42/FITC Conjugated抗体
产品名称： Anti-FBXO42/FITC Conjugated抗体
英文名称： Anti-FBXO42/FITC
产品编号： YB--10560R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
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Anti-FBXO42/FITC Conjugated抗体
| 产品编号 | YB-10560R-FITC |
| 英文名称 | Anti-FBXO42/FITC |
| 中文名称 | FITC标记的FBXO42蛋白抗体 |
| 别 名 | F box only protein 42; F box protein 42; FBX42; FBXO 42; KIAA1332; FBX42_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 78kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXO42 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FBXO42 (F-box only protein 42) is a 717 amino acid protein that contains four Kelch repeats and one N-terminal F-box domain, and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Function: Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Specifically recognizes p53/TP53, promoting its ubiquitination anddegradation. Subunit: Component of some SCF complex, composed of CUL1, SKP1,RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53;interaction is direct. Tissue Specificity: Expressed at moderate levels in liver, ovary, kidney, testis and adult brain, and at low levels in heart and fetal brain, FBXO42 directly interacts with Skp1 p19 and CUL-1. Similarity: Contains 1 F-box domain. Contains 4 Kelch repeats. Database links: Entrez Gene: 54455 Human Omim: 609109 Human SwissProt: Q6P3S6 Human Unigene: 522384 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |