FITC标记的信号通路Wnt16抗体
产品名称： FITC标记的信号通路Wnt16抗体
英文名称： Anti-Wnt16/FITC
产品编号： HZ-9476R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Wnt16/FITC Conjugated antibody
FITC标记的信号通路Wnt16抗体
| 产品编号 | bs-9476R-FITC |
| 英文名称 | Anti-Wnt16/FITC |
| 中文名称 | FITC标记的信号通路Wnt16抗体 |
| 别 名 | Protein Wnt 16 precursor; Protein Wnt-16; Wingless type MMTV integration site family member 16; WNT16; WNT16_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 糖蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Wnt16 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Wnt genes encode a family of secreted extracellular signaling glycoproteins, which function in a variety of important developmental processes such as regulation of cell growth and differentiation. Wnt proteins also play roles in carcinogenesis. Wnt-14, rather than Wnt-15, is preferentially expressed in various types of human cancer. Wnt-15 is expressed in fetal and adult kidney and is most homologous to Wnt-14. Wnt-16, another member in the Wnt family, has two mRNA isoforms, Wnt-16a and Wnt-16b. These isoforms differ in the composition of their 5'UTR and first exon, which results in differential expression. Wnt-16a is expressed only in pancreas, whereas Wnt-16b is highly expressed in adult kidney, placenta, brain, heart and spleen, but not in bone marrow. However, Wnt-16 transcripts are present in bone marrow and cell lines derived from pre-B acute lymphoblastoid leukemia patients carrying the E2A-Pbx1 hybrid gene. Thus, Wnt-16 is a downstream target of E2A-Pbx1, and the Wnt-16-mediated autocrine growth mechanism may contribute to the development of t(1;19) pre-B acute lymphoblastoid leukemias. Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters Subcellular Location: Secreted.extracellular space, extracellular matrix. Tissue Specificity: Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas. Post-translational modifications: Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-81. Palmitoylation is necessary for proper trafficking to cell surface Similarity: Belongs to the Wnt family. Database links: Entrez Gene: 51384 Human Entrez Gene: 93735 Mouse Entrez Gene: 500047 Rat Omim: 606267 Human SwissProt: Q9UBV4 Human SwissProt: Q9QYS1 Mouse Unigene: 272375 Human Unigene: 137403 Mouse Unigene: 209854 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Wnt基因编码一系列分泌的胞外信号糖蛋白，其在多种重要的发育过程中起作用，如调节细胞生长和分化。Wnt蛋白在肿瘤发生过程中也起着重要作用。WNT-14，而不是WNT-15，在各种类型的人类癌症中优先表达。WNT-15在胎儿和成人肾脏中表达，与WNT-14最同源。WNT-16是Wnt家族中的另一成员，具有两种mRNA亚型：WNT-16A和WNT-16B。这些异构体在它们的5' UTR和第一外显子的组成上不同，导致差异表达。WNT-16A仅在胰腺中表达，而WNT-16B在成人肾脏、胎盘、脑、心脏和脾脏中高表达，而在骨髓中不表达。然而，WNT-16转录本存在于来自携带E2A- PBX1杂合基因的前B急性淋巴母细胞白血病患者的骨髓和细胞系中。因此，WNT-16是E2A- PBX1的下游靶点，WNT-16介导的自分泌生长机制可能有助于T（1；19）前B型急性淋巴母细胞白血病的发生。