KCTD12,钾离子通道多聚体结构域蛋白12抗体

产品编号HZ-8673R
英文名称KCTD12
中文名称钾离子通道多聚体结构域蛋白12抗体
别 名C13orf2; BTB/POZ domain-containing protein KCTD12; C13orf2; KCD12_HUMAN; KCTD12; KIAA1778; PFET1; Pfetin; potassium channel tetramerisation domain containing 12 USA; Predominantly fetal expressed T1 domain.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
KCTD12,钾离子通道多聚体结构域蛋白12抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human KCTD12 (261-325aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
KCTD12,钾离子通道多聚体结构域蛋白12抗体PubMedPubMed
产品介绍background:
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (POxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. KCTD12 (potassium channel tetramerisation domain containing 12), also known as PFET1 or PFETIN, is a 325 amino acid protein that is expressed in fetal organs, with highest levels in the cochlea and brain and extremely low levels in adult organs, such as brain and lung. KCTD12 is considered a prognostic biomarker of gastrointestinal stromal tumors.

Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.

Subcellular Location:
Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse > postsynaptic cell membrane.

Tissue Specificity:
Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Database links:
UniProtKB/Swiss-Prot: Q96CX2.1

KCTD12,钾离子通道多聚体结构域蛋白12抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.