分子量:68.2 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human TYRO3, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:Measured by its binding ability in a functional ELISA. Immobilized Human TYRO3, Fc Tag at 2 g/mL (100 l/well) can bind rhGas6 with a linear range of 10 - 100 ng/mL.

产品特性:Human TYRO3, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 68.2 kDa. The predicted N-terminus is Ala 41. The reducing (R) protein migrates as 85-110 kDa in SDS-PAGE  due to glycosylation.

产品背景:Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity.