CDH1 (N-term) Peptide
产品名称： CDH1 (N-term) Peptide
英文名称： CDH1 (N-term) Peptide
产品编号： P0458
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDH1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CDH1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition.
Hsu YM, Chen YF, Chou CY, Tang MJ, Chen JH, Wilkins RJ, Ellory JC, Shen MR.Cancer Res. 2007 Nov 15;67(22):11064-73.
- 2.
- Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.
Knudsen KA, Wheelock MJ.J Cell Biol. 1992 Aug;118(3):671-9.
- 3.
- Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.
Mansouri A, Spurr N, Goodfellow PN, Kemler R.Differentiation. 1988 Jun;38(1):67-71.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CDH1 polyclonal antibody (Cat # PAB3139) in 293 cell line lysates (35 ug/lane). CDH1 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Entrez GeneID:
- 999
- Protein Accession#:
- NP_004351;P12830
- Gene Name:
- CDH1
- Gene Alias:
- Arc-1,CD324,CDHE,ECAD,LCAM,UVO
- Gene Description:
- cadherin 1, type 1, E-cadherin (epithelial)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
- Other Designations:
- cadherin 1, E-cadherin (epithelial),cadherin 1, type 1,calcium-dependent adhesion protein, epithelial,cell-CAM 120/80,uvomorulin
- Related Disease
- Adenocarcinoma
- Asthma
- Asthma
- Breast cancer
- Breast Neoplasms
- Bronchiolitis, Viral
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Large Cell
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Cleft Lip
- Cleft Palate
- Colitis, Ulcerative
- Colorectal Neoplasms