FITC标记的主导控制样蛋白3抗体
产品名称： FITC标记的主导控制样蛋白3抗体
英文名称： Anti-MAML3/FITC
产品编号： HZ-12398R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MAML3/FITC Conjugated antibody
FITC标记的主导控制样蛋白3抗体
| 英文名称 | Anti-MAML3/FITC |
| 中文名称 | FITC标记的主导控制样蛋白3抗体 |
| 别 名 | AV234550; BC049812; CAGH3; ERDA3; GDN; KIAA1816; MAM 2; MAM2; mastermind like 3 (Drosophila); MGC59565; mKIAA1816; TNRC3; MAML3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 干细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 122kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAML3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The three MAML genes are widely expressed in adult tissues but exhibit distinct expression patterns in mouse early spinal cord development. All MAML proteins localize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini. MAML3 acts as a transcriptional coactivator for NOTCH proteins and has been shown to amplify NOTCH-induced transcription of HES1. Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Subunit: Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Subcellular Location: Nucleus; nuclear speckle. Note=Nuclear, in a punctate manner Similarity: Belongs to the mastermind family. Database links: UniProtKB/Swiss-Prot: Q96JK9.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
这三个MAML基因在成年组织中广泛表达，但在小鼠早期脊髓发育中表现出不同的表达模式。所有的MAML蛋白都定位于核小体，在它们的N端共享一个保守的基本结构域，该结构域与Notch的ankyrin重复结构域结合，并且在它们的C端包含一个转录激活结构域。MAML3作为Notch蛋白的转录共激活子，已被证明能扩增Notch诱导的HES1转录。